I ran into a problem running Tropico 6 on Gentoo where left mouse clicks to select would not work. I found this was a problem for other Linux users, particularly of Gentoo. The fix: Unreal Engine 4 (UE4) games like Tropico 6 require a legacy mouse module mousedev which is often not built unless necessary on advanced distros. Credit to sixsupersonic for tracking down the UE4 issue.